Alternative polyadenylation is emerging as an important mechanism in the post-transcriptional regulation of gene expression across eukaryotic species. Recent studies have shown that APA plays key roles in diverse biological process, such as cell differentiation and cell proliferation. Notably, APA often occurs in a tissue-specific and cell-type-specific manner. The scAPAatlas is designed to explore cell-type-specific APA events across different cell types in human and mouse.
In scAPAatlas, it includes:
- The taxonomy of cell types in different tissues;
- The APA landscape of different cell types;
- Cell-type-specific APA events in different tissues;
- APA events correlated with gene expression level;
- miRNAs binding on 3'UTR altered by cell-type-specific APA events;
- RBPs binding on 3'UTR altered by cell-type-specific APA events.
